Contact Information:
DDykxhoorn@med.miami.edu
Assistant: Karen Neagley
Hussman Institute for Human Genomics
1501 NW 10th Ave.
Miami, FL 33136
ph: 305-243-2064
fax: 305-243-2396

 

Derek Dykxhoorn, Ph.D.

Derek M. Dykxhoorn, Ph.D., is an Assistant Professor in the Dr. John T. Macdonald Foundation Department of Human Genetics and the Department of Microbiology and Immunology. Dr. Dykxhoorn is a molecular biologist interested in the role that small regulatory RNA molecules, microRNAs and small interfering RNAs, play in the pathogenesis of various diseases. He has worked extensively at developing tools that can harness these endogenous regulatory mechanisms as potential genetic therapies against several diseases, including HIV-1 and cancer.

Links

   

Selected Publications

  1. Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell 31(1):33-46, 2008.
  2. Martinvalet D, Dykxhoorn DM, Ferrini R, Lieberman J. Granzyme. A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell 133(4):681-92, 2008.
  3. Dykxhoorn DM, Chowdhury D, Lieberman J. RNA interference and cancer: endogenous pathways and therapeutic approaches. Adv Exp Med Biol 615:299-329, 2008.
  4. Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R, Jr., Srikantan S, Subrahmanyam R, Martindale JL, Yang X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M. p16(INK4a) translation suppressed by miR-24. PLoS ONE 3(3):e1864, 2008.
  5. Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. Identification of host proteins required for HIV infection through a functional genomic screen. Science 319(5865):921-6, 2008.
  6. Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE. Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia 21(8):1723-32, 2007.
  7. Dykxhoorn DM. MicroRNAs in viral replication and pathogenesis. DNA Cell Biol 26(4):239-49, 2007.
  8. Dykxhoorn DM, Schlehuber LD, London IM, Lieberman J. Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. Proc Natl Acad Sci U S A 103(15):5953-8, 2006.
  9. Dykxhoorn DM, Lieberman J. Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. Annu Rev Biomed Eng 8(377-402, 2006.
  10. Dykxhoorn DM, Lieberman J. Silencing viral infection. PLoS Med 3(7):e242, 2006.
  11. Dykxhoorn DM, Lieberman J. Knocking down disease with siRNAs. Cell 126(2):231-5, 2006.
  12. Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM, Feng Y, Palliser D, Weiner DB, Shankar P, Marasco WA, Lieberman J. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol 23(6):709-17, 2005.
  13. Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, Francois-Bongarcon V, Goldfeld A, Swamy NM, Lieberman J, Shankar P. Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. Blood 106(3):818-26, 2005.
  14. Dykxhoorn DM, Lieberman J. The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annu Rev Med 56(401-23, 2005.
  15. Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P. Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J Virol 77(13):7174-81, 2003.
  16. Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol 4(6):457-67, 2003.
  17. Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK, Collman RG, Lieberman J, Shankar P, Sharp PA. siRNA-directed inhibition of HIV-1 infection. Nat Med 8(7):681-6, 2002.